What should be monitored prior to each infusion of zoledronic acid?

Monitoring serum creatinine prior to each infusion of zoledronic acid is essential because this medication is primarily eliminated by the kidneys. It is important to assess renal function before administration to prevent potential nephrotoxicity. Zoledronic acid can cause acute kidney injury, especially in patients with pre-existing renal impairment or dehydration. By checking serum creatinine levels, healthcare providers can determine if the patient's renal function is sufficient to handle the infusion safely.

While blood pressure, heart rate, and potassium levels are important in various clinical settings, they do not have the same direct relationship to the administration of zoledronic acid as renal function does. Monitoring serum creatinine specifically helps to ensure that the patient can tolerate the drug without significant risk for kidney damage.